Table 1 List of proteins involved in EV biogenesis present in Sparicotyle chrysophrii

ESCRT-0

HGS ^a

Schistosoma mansoni

6.38E−33

–

STAM ^a

Schistosoma japonicum

3.56E−19

–

STAMBP ^a

Clonorchis sinensis

2.92E−63

2.47E−57

ESCRT-I

TSG101 ^a

Schistosoma japonicum

2.70E−18

8.25E−22

VPS28 ^a

Schistosoma japonicum

5.35E−35

1.09E−13

MVB12 ^a

Fasciola gigantica

1.66E−40

–

ESCRT-II

VPS SNF8 ^a

Paragonimus westermani

2.22E−40

2.34E−66

VPS25 ^a

Schistosoma haematobium

2.07E−74

–

VPS36 ^a

Homo sapiens

7.08E−44

9.67E−48

ESCRT-III

CHMP1a ^a

Homo sapiens

4.53E−41

2.05E−58

CHMP1b ^a

Fasciolopsis buski

2.40E−47

–

CHMP2a ^a

Homo sapiens

1.62E−24

–

CHMP2b ^a

Homo sapiens

1.10E−35

3.84E−41

CHMP3 ^a

Clonorchis sinensis

2.04E−20

–

CHMP4 ^a

Homo sapiens

3.17E−21

1.10E−32

CHMP5 ^a

Homo sapiens

3.64E−46

–

CHMP6 ^a

Homo sapiens

4.69E−10

1.48E−17

IST1 ^a

Homo sapiens

2.97E−45

1.81E−57

ESCRT-associated proteins

VPS4 ^a

Homo sapiens

1.25E−45

0

VTA1 ^a

Paragonimus heterotremus

8.08E−25

–

ALIX ^{a, b}

Echinococcus granulosus

1.41E−03

–

LITAF ^a

Paragonimus heterotremus

3.37E−11

–

Non-canonical ESCRT-associated

SDC1 ^b

Schistosoma mansoni

1.70E−11

–

SDCBP ^b

Homo sapiens

1.80E−08

–

Ral-A ^b

Homo sapiens

6.66E−46

–

ARF6 ^{b, d}

Schistosoma japonicum

8.52E−71

–

PLD2 ^{b, d}

Echinococcus granulosus

8.28E−16

–

Lipid-modifying

SMPD2^{c, d}

Homo sapiens

1.28E−04

8.86E−25

SMS2 ^c

Fasciola hepatica

2.81E−105

–

SPHK2 ^c

Schistosoma haematobium

1.57E−11

–

LTA4H ^c

Homo sapiens

5.61E−140

1.74E−140

DGK ^c

Homo sapiens

3.63E−18

3.50E−58

Lipid transport

ABCA ^{c, d}

Homo sapiens

8.22E−117

3.30E−152

PLSCR ^d

Schistosoma japonicum

5.56E−12

–

OSBP ^c

Schistosoma bovis

2.81E−49

–

NPC1 ^c

Homo sapiens

1.90E−15

2.07E−66

NPC2 ^c

Clonorchis sinensis

4.55E−10

3.3E−28

Signalling

ARF1 ^d

Homo sapiens

1.13E−83

–

ROCK1 ^d

Fasciolopsis buski

6.42E−65

–

ROCK2 ^d

Schistosoma japonicum

1.24E−50

–

DIAPH3 ^d

Homo sapiens

2.87E−62

1.87E−65

MYLK3 ^d

Paragonimus heterotremus

0

2.99E−35

MAPK3 ^d

Fasciola hepatica

2.06E−35

Cytoskeleton remodelling

CAPN1 ^d

Homo sapiens

1.22E−38

2.62E−70

GELS ^d

Echinococcus multilocularis

1.50E−10

3.74E−36

Membrane organisers

CD63

Clonorchis sinensis

2.09E−21

–

FLOT1

Homo sapiens

2.13E−35

1.75E−115

FLOT2

Homo sapiens

2.19E−28

1.54E−142

SNAREs

STX1A

Echinococcus granulosus

1.40E−42

–

STX5

Fasciola gigantica

1.49E−17

–

YKT6

Paragonimus westermani

9.34E−10

–

SYT1

Schistosoma japonicum

3.20E−28

–

VAMP3

Homo sapiens

4.34E−14

–

RNA sorting and transport

hnRNPA2B1

Homo sapiens

1.69E−52

6.73E−59

NSEP1

Homo sapiens

1.83E−30

3.36E−38

hnRNPQ

Opisthorchis viverrini

7.42E-90

–

Ago2

Homo sapiens

1.48E−53

0

MVP

Schistosoma bovis

1.06E−60

1.81E−116

Other vault complex proteins

PARP4

Schistosoma mansoni

4.92E−28

–