Evaluation of the performance of advantage P.f. malaria Card® and advantage malaria Pan + Pf Card®, two rapid diagnostic tests for parasitological confirmation of malaria cases in field situation in Togo

Table 4 Performance levels of RDTs evaluated against TTBS and PCR for the detection of Plasmodium falciparum

	Advantage Malaria P.f. card®	Advantage Malaria Pan + Pf Card®
Microscopy as reference method
Low parasitemia^a
SE^b [95% CI]	88.7 [81.9–93.2]	87.9 [81.1–92.7]
PPV^b [95% CI]	94.0 [88.8–96.9]	93.9 [88.7–96.8]
High parasitemia^a
SE^b [95% CI]	97.4 [90.2–99.6]	97.4 [90.2–99.6]
PPV [95% CI]	89.4 [81.7–94.1]	89.4 [81.7–94.1]
Total
SE [95% CI]	91.8 [87.1–94.9]	91.3 [86.6–94.6]
SP^b [95% CI]	94.7 [90.0–97.4]	94.7 [90.0–97.4]
PPV [95% CI]	95.7 [92.2–97.7]	95.7 [92.2–97.7]
NPV^b [95% CI]	90.0 [85.2–93.3]	89.5 [84.7–92.9]
PCR as reference method
SE [95% CI]	84.2 [84.7–92.8]	83.8 [78.5–88.2]
SP [95% CI]	96.5 [92.0–98.9]	96.5 [92.0–98.9]
PPV [95% CI]	97.6 [94.4–99.0]	97.6 [94.4–99.0]
NPV [95% CI]	78.4 [71.5–84.1]	78.0 [71.0–83.6]

^aLow parasitemia = 50–100 asexual parasitemia/µl, high parasitemia = 2000–10000 asexual parasitemia/µl
^bSE = sensitivity, SP = specificity; PPV = positive predictive value; NPV = negative predictive value

ISSN: 1756-3305