Fig. 1

Different effects of PfK13 mutation on the transcriptome and proteome of Plasmodium falciparum at different stages. A Heat map of all differentially expressed genes (DEGs) (P. falciparum 3D7^C580Y/P. falciparum 3D7^WT). B DEGs at different stages (|log₂ fold change (FC)| ≥ 1, P < 0.05; the minimum number of reads for at least one sample had to exceed 100). C Plasmodium falciparum 3D7^WT and P. falciparum 3D7^C580Y at different stages. D Heat map of differentially expressed proteins (DEPs) (P. falciparum 3D7^C580Y/P. falciparum 3D7^WT). E DEPs at 12, 24, and 30 h post-infection (hpi) (|log₂FC| ≥ 1, P < 0.05)