Fig. 7

RH-Δompdc treatment increased the levels of IL-12 and IFN-γ in both the serum and TME. The 4T1 tumor-bearing mice model was established as illustrated in Fig. 5a, and the levels of the cytokines IL-12 and IFN-γ in the serum and TME were determined by ELISA at 1, 8, and 13 days after the first treatment. a, b Levels of IL-12 (a) and IFN-γ (b) in the serum were detected (n = 4). c, d Levels of IL-12 (c) and IFN-γ (d) in the TME were detected (n = 3). Results are representative of three independent experiments. Data were analyzed by two-way ANOVA with Tukey’s test. Asterisks indicate significant difference at *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001