Skip to main content
Fig. 4 | Parasites & Vectors

Fig. 4

From: Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan

Fig. 4

Structural alignment between LiTop1B (PDB 2b9s) and hTop1B crystallized in covalent complex with DNA and in the presence of the inhibitor topotecan (PDB 1k4t). The large and small subunits from the dimeric structure of LiTOP1B are shown in green and orange, respectively, while hTop1B is reported in light blue, and topotecan is shown in yellow. The insert panel shows topotecan together with the structural alignment of residues forming the binding pocket (hR364, hD533, and hN722) and the residues of LiTOP1B that, if mutated, lead to drug resistance (LiF187, LiG191, and LiW242)

Back to article page

Parasites & Vectors

ISSN: 1756-3305

Contact us