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Fig. 3 | Parasites & Vectors

Fig. 3

From: In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei

Fig. 3

Effect of salinomycin derivatives on the cell volume of bloodstream forms of T. brucei. Trypanosomes (5 × 107 cell/ml) were incubated with 100 μM salinomycin (closed circles), SAL-E7 (open circles), SAL-AM2 (open squares), SAL-E4 (open triangles), or SAL-AM1 (open diamonds) in culture medium. Every 15 min, the absorbance at 490 nm was measured. Mean values ± SD of three experiments are shown. At the time points 30 and 45 min, the values for SAL-E7 and SAL-AM2 were statistically significantly different from the values for salinomycin (P < 0.05). At the time points 15, 30, 45 and 60 min, the values for SAL-E4 and SAL-AM1 were statistically significantly different from the values for salinomycin (P < 0.05). Note that a decrease in absorbance corresponds to an increase in cell volume

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