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Table 2 IC50 values generated by resazurin, CellTiter-Glo® and Vybrant® compared to microscopic values

From: Fluorescence/luminescence-based markers for the assessment of Schistosoma mansoni schistosomula drug assays

 

Resazurin

CellTiter-Glo®

Vybrant®

Drug

IC50 SpectraMax (μM)

IC50 Microscopic Readout (μM)

IC50 SpectraMax (μM)

IC50 Microscopic Readout (μM)

IC50 SpectraMax (μM)

IC50 Microscopic Readout (μM)

Praziquantel

not calculable

1.7 ± 1.5

not calculable

1.3 ± 0.9

not calculable

2.4 ± 1.2

Mefloquine

not calculable

2.6 ± 1.1

4.9 ± 2.9

2.4 ± 1.3

7.9 ± 1.7

1.7 ± 0.3

Oxamniquine

not calculable

135.1 ± 128.8

194.5 ± 52.6

87.7 ± 49.7

not calculable

20.3 ± 9.5

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Parasites & Vectors

ISSN: 1756-3305

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