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Table 2 Presence of Leishmania donovani DNA in various tissues of BALB/c mice

From: Xenodiagnosis of Leishmania donovani in BALB/c mice using Phlebotomus orientalis: a new laboratory model

 

Mice sacrificed 8 weeks p.i.

Mice sacrificed 15 weeks p.i.

 

#3

#4

#6

#8

#10

#1

#2

#5

#7

#9

Inoculated ear (IE)

++

+++

++++

++++

neg.

+

++

+++

++++

++++

Contralateral ear (CE)

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

+

++

Draining lymph node of the IE

+++

+++

++++

++++

neg.

neg.

neg.

++++

+++++

+++++

Draining lymph node of the CE

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

Paws

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

Tail

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

neg.

Spleen*

+

++

+

++

+++

neg.

neg.

++

++

++

Liver

neg.

neg.

neg.

+

neg.

neg.

neg.

+

++

++

Blood

n.d.

n.d.

neg.

neg.

++

n.d.

n.d

neg.

neg.

neg.

  1. *Spleens of mice 5, 7 and 9 were positive also by parasite cultivation; in other mice cultivation attempts were not done.
  2. Quantity of parasites was tested by qPCR and scored as + (<102), ++ (102-103), +++ (103-104), ++++ (104-105), +++++ (>105).
  3. neg., negative, n.d., not done; p.i., post infection.
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