Table 3 Components of the insect JAK/STAT pathway identified in the C. sonorensis transcriptome

Receptors

Domeless (Dome)

GAWM01016058

m.63662

AAEL012471

CPIJ017416

4.38e-85

Partial; Transmembrane Receptor, Domeless; has 2 fibronectin III (FNIII) domains

GAWM01016156

m.64065

AAEL012471

CPIJ017416

4.38e-85

Complete; Transmembrane Receptor, Domeless; has 3 extracellular FNIII like domains

Cell signaling

Hopscotch janus kinase (Hop)

GAWM01005626

m.25895

AAEL012553

CPIJ001760

0

Complete; Janus Kinase (JAK) signature; confirmed domains: ferm domain, SH2 domain, two TK domains

Transcription

Signal transducer and activator of transcription (STAT)

GAWM01007780

m.32041

AAEL013265

CPIJ016471

1.01e-43

Partial; has p53 domain, SDE2 domain, STAT domain

GAWM01011778

m.45760

AAEL013265

CPIJ016471

1.01e-43

Partial; missing STAT coiled coil domain

GAWM01013279

m.51827

AAEL013265

CPIJ016471

1.01e-43

Complete; Stat-4 N-domain, AA 1–128; coiled coil, AA 132–327, STAT DNA-binding domain (P53 like), AA 328–467, EF-hand domain, AA 468–590, SH2 domain, AA 566-698

Regulators

Suppressor of cytokine signaling 5 (SOCS36E?)

GAWM01008465

m.34186

AAEL000393

CPIJ003380

5.70e-102

Complete SOCS box, C-terminal; SH2 domain; confirmed in insects as JAK/STAT repressor

Suppressor of cytokine signaling (SOCS7?)

GAWM01008657

m.34752

AAEL006949

CPIJ003985

1.62e-104

Complete SOCS box, C-terminal; SH2 domain; homologous to Drosophila SOCS16D; function unknown

Protein inhibitor of activated stat; PIAS, sumo ligase

GAWM01011450

m.44071

AAEL015099

CPIJ009163

1.66e-150

Complete; SAP domain; PINIT domain; Zinc finger, MIZ-type; Zinc finger, RING/FYVE/PHD-type

GAWM01011451

m.44074

AAEL015099

CPIJ009163

1.66e-150

Complete; SAP domain; PINIT domain; Zinc finger, MIZ-type; Zinc finger, RING/FYVE/PHD-type