Trial name/first author of study(year) [reference] | Dosage of ivermectin | Results: mortality of mosquito |
---|---|---|
ACTIVE [24] 2013 Burkina Faso | 200 µg/kg as a single dose or 200 µg/kg for 2 days as two doses or placebo; all administered with artemether-lumefantrine | An. gambiae Mortality of mosquito in 3 days post blood meal (one dose of Ivermectin): 33% Mortality of mosquito in 3 days post blood meal (two doses of Ivermectin): 31% Controls: 6% mortality in 3 days (difference was significant) Mortality of mosquito in 10 days post blood meal (one dose of Ivermectin): 59% Mortality of mosquito in 10 days post blood meal (2 doses of Ivermectin): 66% Controls: 21% mortality in 10 days (difference was significant) An. funestus Mortality of mosquito in 3 days post blood meal (one dose of Ivermectin): 33% Mortality of mosquito in 3-days post blood meal (two doses of Ivermectin): 22% Controls: 3% mortality in 3 days (difference was significant) Mortality of mosquito in 10 days post blood meal (one dose of Ivermectin): 40% Mortality of mosquito in 10 days post blood meal (two doses of Ivermectin): 51% Controls: 5% mortality in 10 days (difference was significant) |
RIMDAMAL [15] 2015 Burkina Faso | First dose of 150–200 µg/kg single dose with 400 mg albendazole plus five further similar ivermectin doses at 3-week intervals | Frequently repeated mass administration of ivermectin during the malaria transmission season led to significant reduction in malarial episodes in children |
IVERMAL [25] 2015 Kenya | 300 µg/kg for 3 days or 600 µg/kg for 3 days or placebo; all administered with dihydroartemisinin-piperaquine | 3-Day ivermectin treatment at either of the doses reduced mosquito survival for at least 28-days-post feeding |
Derua [26] 2015 Tanzania | 150–200 μg/kg | Mortality of mosquito in 3 days post blood meal: 66.2% Mortality of mosquito in 9 days post blood meal: 95% Significance not reported |
Sampaio [27] 2016 Brazil | 200 µg/kg | Ivermectin treatment reduces mosquito survivorship by 4 h to 14 days |
Kobylinski [28] 2017 Thailand | 200 µg/kg | Ivermectin was lethal to dominant GMS Anopheles malaria vectors and inhibited sporogony of P. vivax at safe human relevant concentrations |
Mekuriaw [14] 2019 Ethiopia | Single oral dose of 12 mg | Significant higher mortality of mosquitos on days 1 and day 4 reported |