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Table 1 Major ivermectin studies in humans

From: Ivermectin as an endectocide may boost control of malaria vectors in India and contribute to elimination

Trial name/first author of study(year) [reference]

Dosage of ivermectin

Results: mortality of mosquito

ACTIVE [24]

2013

Burkina Faso

200 µg/kg as a single dose or 200 µg/kg for 2 days as two doses or placebo; all administered with artemether-lumefantrine

An. gambiae

Mortality of mosquito in 3 days post blood meal (one dose of Ivermectin): 33%

Mortality of mosquito in 3 days post blood meal (two doses of Ivermectin): 31%

Controls: 6% mortality in 3 days (difference was significant)

Mortality of mosquito in 10 days post blood meal (one dose of Ivermectin): 59%

Mortality of mosquito in 10 days post blood meal (2 doses of Ivermectin): 66%

Controls: 21% mortality in 10 days (difference was significant)

An. funestus

Mortality of mosquito in 3 days post blood meal (one dose of Ivermectin): 33%

Mortality of mosquito in 3-days post blood meal (two doses of Ivermectin): 22%

Controls: 3% mortality in 3 days (difference was significant)

Mortality of mosquito in 10 days post blood meal (one dose of Ivermectin): 40%

Mortality of mosquito in 10 days post blood meal (two doses of Ivermectin): 51%

Controls: 5% mortality in 10 days (difference was significant)

RIMDAMAL [15]

2015

Burkina Faso

First dose of 150–200 µg/kg single dose with 400 mg albendazole plus five further similar ivermectin doses at 3-week intervals

Frequently repeated mass administration of ivermectin during the malaria transmission season led to significant reduction in malarial episodes in children

IVERMAL [25]

2015

Kenya

300 µg/kg for 3 days or 600 µg/kg for 3 days or placebo; all administered with dihydroartemisinin-piperaquine

3-Day ivermectin treatment at either of the doses reduced mosquito survival for at least 28-days-post feeding

Derua [26]

2015

Tanzania

150–200 μg/kg

Mortality of mosquito in 3 days post blood meal: 66.2%

Mortality of mosquito in 9 days post blood meal: 95%

Significance not reported

Sampaio [27]

2016

Brazil

200 µg/kg

Ivermectin treatment reduces mosquito survivorship by 4 h to 14 days

Kobylinski [28]

2017

Thailand

200 µg/kg

Ivermectin was lethal to dominant GMS Anopheles malaria vectors and inhibited sporogony of P. vivax at safe human relevant concentrations

Mekuriaw [14]

2019

Ethiopia

Single oral dose of 12 mg

Significant higher mortality of mosquitos on days 1 and day 4 reported