Compound | S. haematobium adult 72 h IC50 (μM) | Onset of action 100 μM (h) | Most affected sex | Tegumental damage | ||
---|---|---|---|---|---|---|
Blebbing | Sloughing off | Specific damage pattern/organ | ||||
Fc-OXA | 68.1 | 48 | Males | + | ++ | Gynaecophoric canal |
Rc-OXA | 24.5 | 24 | Males | ++ | ++ | Loss of spines |
Bn-OXA | 38.6 | 48 | Males | + | +++ | Body creases |
OXA | > 100 | 120 | Both | + | β | VS invagination |