Skip to main content

Table 2 Study 2 tick counts in untreated control and lotilaner-treated dogs when live ticks were removed at 72 h post-treatment and at 72 h following each post-treatment infestation

From: Laboratory evaluations of the 3-month efficacy of oral lotilaner (Credelio™) against experimental infestations of dogs with the Australian paralysis tick, Ixodes holocyclus

Day of study

Arithmetic mean ± SD

Geometric mean

t-value

P-value

Efficacy (%)a

Control

Lotilaner

Control

Lotilaner

3

22.3 ± 3.5

0.0 ± 0.0

22.0

0

100

17

24.1 ± 1.3

0.0 ± 0.0

24.1

0

100

31

25.9 ± 2.0

0.0 ± 0.0

25.8

0

100

45

23.4 ± 4.3

0.0 ± 0.0

23.0

0

100

59

24.6 ± 2.3

0.0 ± 0.0

24.5

0

100

73

23.6 ± 2.7

0.8 ± 2.1

23.5

0.3

t(266)=8.5

<0.0001

98.8

80

26.1 ± 1.6

2.9 ± 8.1

26.1

0.5

t(266)=11.0

<0.0001

98.1

87

26.3 ± 3.9

4.1 ± 8.4

26.0

1.2

t(266)=11.3

<0.0001

95.3

  1. aEfficacy based on geometric means
  2. Abbreviation: SD, standard deviation
  3. †For efficacy values of 100%, the statistical method does not produce a t- or P-value