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Table 2 Genetic polymorphisms and tests of neutrality for global PfMSP-142

From: Genetic diversity of merozoite surface protein-1 C-terminal 42 kDa of Plasmodium falciparum (PfMSP-142) may be greater than previously known in global isolates

Allele type/ Country (No. of sequences)

K

H

Hd ± SD

π ± SD

dN-dS

Tajima’s D (P-value)

Block15

Block16

Block17

Full

Block15

Block16

Block17

Full

MAD20

 Myanmar

(n = 37)

4.300

21

0.902 ± 0.040

0.00313 ± 0.00049

0.00272 ± 0.00035

0.00533 ± 0.00062

0.00351 ± 0.00033

0.0208

0.50117

(P>0.10)

-0.65200

(P>0.10)

0.23510

(P>0.10)

-0.18385

(P>0.10)

 Thailand

(n = 29)

2.620

6

0.473 ± 0.110

0.00153 ± 0.00048

0.00156 ± 0.00050

0.00364 ± 0.00094

0.00214 ± 0.00055

0.0027

0.25334

(P>0.10)

-0.42016

(P>0.10)

-0.53026

(P>0.10)

-0.46786

(P>0.10)

 Philippines

(n = 24)

3.880

5

0.652 ± 0.081

0.00268 ± 0.00018

0.00144 ± 0.00014

0.00694 ± 0.00082

0.00317 ± 0.00033

0.0040

1.57336

(P>0.10)

1.89198

(0.05<P<0.10)

2.22277

(P<0.05)

2.60308

(P<0.01)

 PNG

(n = 44)

4.098

7

0.753 ± 0.034

0.00263 ± 0.00011

0.00220 ± 0.00013

0.00607 ± 0.00029

0.00335 ± 0.00011

0.0035

1.67820

(P>0.10)

0.80323

P>0.10

1.99671

(0.05<P<0.10)

1.84977

(0.05<P<0.10)

 SI

(n = 17)

3.985

4

0.596 ± 0.099

0.00251 ± 0.00041

0.00205 ± 0.00036

0.00612 ± 0.00097

0.00326 ± 0.00052

0.0014

1.23804

(P>0.10)

1.67363

(P>0.10)

1.32924

(P>0.10)

1.79153

(0.05<P<0.10)

 Vanuatu

(n = 48)

2.052

3

0.228 ± 0.075

0.00116 ± 0.07200

0.00097 ± 0.00031

0.00339 ± 0.00110

0.00168 ± 0.00054

0.0019

-0.01160

(P>0.10)

-0.01781

(P>0.10)

-0.36701

(P>0.10)

-0.25695

(P>0.10)

 Ghana

(n = 23)

3.715

14

0.925 ± 0.041

0.00086 ± 0.00051

0.00324 ± 0.00019

0.00385 ± 0.00097

0.00304 ± 0.00029

0.0038

-0.66215

(P>0.10)

1.91092

(0.05<P<0.10)

-0.09195

(P>0.10)

0.84400

(P>0.10)

 Tanzania

(n = 51)

3.585

29

0.958 ± 0.014

0.00041 ± 0.00027

0.00296 ± 0.00028

0.00430 ± 0.00060

0.00293 ± 0.00023

0.0035

-1.46227

(P>0.10)

0.05855

(P>0.10)

0.25010

(P>0.10)

-0.15863

(P>0.10)

K1

 Myanmar

(n = 18)

1.431

6

0.765 ± 0.080

0.00214 ± 0.00037

0.00102 ± 0.00037

0.00093 ± 0.00042

0.00120 ± 0.00026

-0.0012

1.16615

(P>1.10)

-1.34736

(P>0.10)

-1.09629

(P>0.10)

-1.00674

(P>0.10)

 Thailand

(n = 12)

0.742

3

0.530 ± 0.136

0

0

0.00215 ± 0.00081

0.00062 ± 0.00023

0.0008

0

0

-0.82879

(P>0.10)

-0.82879

(P>0.10)

RO33

 Myanmar

(n = 14)

1.506

6

0.736 ± 0.109

0.00074 ± 0.00062

0.00115 ± 0.00039

0.00168 ± 0.00108

0.00123 ± 0.00041

0.0015

-1.15524

(P>0.10)

-1.22200

(P>0.10)

-1.79759

(P>0.10)

-1.79616

(P>0.10)

 Thailand

(n = 33)

2.375

6

0.680 ± 0.060

0.00088 ± 0.00043

0.00058 ± 0.00025

0.00529 ± 0.00055

0.00195 ± 0.00028

0.0024

-0.46603

(P>0.10)

-1.04700

(P>0.10)

1.23456

(P>0.10)

0.21599

(P>0.10)

 Philippines

(n = 19)

2.023

4

0.678 ± 0.088

0

0

0.00593 ± 0.00083

0.00166 ± 0.00023

0.0021

0

0

1.28875

(P>0.10)

1.28875

(P>0.10)

 PNG

(n = 33)

2.257

4

0.447 ± 0.093

0.00179 ± 0.00043

0.00144 ± 0.00030

0.00270 ± 0.00076

0.00185 ± 0.00047

0.0023

0.60324

(P>0.10)

0.78518

(P>0.10)

0.56203

(P>0.10)

0.89252

(P>0.10)

 SI

(n = 24)

0.811

3

0.236 ± 0.109

0.00118 ± 0.00053

0.00024 ± 0.00022

0.00122 ± 0.00110

0.00066 ± 0.00048

0.0008

-0.24844

(P>0.10)

-1.51469

(P>0.10)

-1.99611

(P<0.05)

-1.99292

(P<0.05)

 Vanuatu

(n = 43)

1.278

2

0.432 ± 0.057

0

0

0.00375 ± 0.00051

0.00106 ± 0.00014

0.0013

0

0

0.90772

(P>0.10)

0.90772

(P>0.10)

 Ghana

(n = 10)

4.022

6

0.844 ± 0.103

0.00242 ± 0.00068

0.00252 ± 0.00056

0.00534 ± 0.00144

0.00329 ± 0.00054

0.0041

0.81980

(P>0.10)

0.86725

(P>0.10)

0.12431

(P>0.10)

0.61111

(P>0.10)

 Tanzania

(n = 20)

3.694

13

0.953 ± 0.028

0

0.00250 ± 0.00030

0.00437 ± 0.00086

0.00303 ± 0.00032

0.0038

0

0.37812

(P>0.10)

-0.37024

(P>0.10)

0.03013

(P>0.10)

  1. Abbreviations: K average number of pairwise nucleotide differences, Hd haplotype diversity, π observed average pairwise nucleotide diversity, dN rate of non-synonymous mutations, dS rate of synonymous mutations, PNG Papua New Guinea, SI Solomon Islands