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Fig. 2 | Parasites & Vectors

Fig. 2

From: Physiological and immunological responses to Culicoides sonorensis blood-feeding: a murine model

Fig. 2

Damage of abdominal dermis in BALB/c mice following feeding by Culicoides sonorensis. Representative images at 1–3 days post-feeding (dpf). a 1 dpf with bite marks (circles), subcutaneous hematomas (arrowhead), and vasodilation (arrow) 10×. b By 2 dpf, subcutaneous hematomas were clearing (arrowhead), vasodilation was still apparent (arrow) and bite sites were diminishing except in areas where a bite had bisected a capillary (circles) 20×. c By 3 dpf, hematomas had largely been reabsorbed and vascular damage was restricted to areas directly damaged during feeding (arrow) 20×. d Abdominal skin of unexposed, naive mouse 7.5×. e H&E staining of micro-thin cross sections of mouse skin at 1 dpf showing damage to epidermis (e) associated with extravasated erythrocytes in the hypodermis (d) (arrow). f By 2 dpf, infiltrating leukocytes were seen at bite sites and the majority of extravasated erythrocytes had been cleared (arrow). g At 3 dpf, infiltrating leukocyte numbers in focal areas decreased (arrow), but were still more prevalent than that seen in the abdominal skin of naïve mice not exposed to feeding Culicoides midges (H). Magnifications of e-h: 200×; scale-bars: 500 μm

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