Table 1 Relative effects of the agents tested on mf motility at 3 and 5 days of culture at 1.25 and 10 μg/ml (% reduction from controls) and the CR₅₀ values after 5 days incubation

1 (Highly effective)

MFQ

1.8

100

9.3

100

3.9 ± 0.1

3.8

3.9

0.16

3.7–4.0

AMQ

2.7

70.6

29.8

95.1

4.1 ± 0.1

4

4.1

0.1

4.0–4.1

2

CQ

3.7

10.3

31.3

63.3

8 ± 0.2

8

8

0.37

7.7–8.3

H-FLBZ

7

36.8

0.9

42.5

8.1 ± 0.7

8.1

8

1.36

6.9–9.3

IVM

2

24.4

5

50.6

8.7 ± 0.5

8.6

8.7

0.83

8.1–9.3

ATS

0.3

5.6

6.5

45.4

9.9 ± 1.4

10.1

9.8

2.58

7.7–12.1

3

QN

0.4

36.4

2.7

36.5

12.7 ± 0.9

12.9

12.7

1.65

11.8–13.6

GLV

0.5

25.2

1.3

42.1

13.4 ± 2.6

12.8

13.2

4.64

9.3–17.5

4

R-FLBZ

0.6

24.2

10.2

25.8

17.6 ± 3

17.8

17.5

5.56

12.9–22.4

FLBZ

7.2

18.5

12.9

25.3

21.2 ± 3.2

21.2

21

5.79

16.1–26.3

SCYX-7851

0.1

18.1

1

31.4

25.4 ± 5.6

24.6

24.9

10.64

20.3–30.6

5 (Not effective)

PZQ

0.2

3.1

2.1

3.5

–

–

–

–

–

Fexinidazole

0.4

0.6

1.6

2.6

–

–

–

–

–