Size and sequence polymorphisms in the glutamate-rich protein gene of the human malaria parasite Plasmodium falciparum in Thailand

Table 1 Summary of statistics for the GLURP R2 region in P. falciparum populations and tests for departure from neutrality

Population	n	GLURP subtype	hd ± SD	π ± SD	Tajima’s D	Fu and Li’s D*	Fu and Li’s F*
Thailand	65	28	0.833 ± 0.038	0.00611 ± 0.00058	-0.53408 (P > 0.10)^a	0.80029 (P > 0.10)	0.38828 (P > 0.10)
India	81	68	0.944 ± 0.016	0.00377 ± 0.00103	-0.29581 (P > 0.10)	-0.88322 (P > 0.10)	-0.79358 (P > 0.10)
Indonesia	3	3	1 ± 0.272	0.00102 ± 0.00064	nd	nd	nd
Iran	2	1	0	0	nd	nd	nd
China	2	2	1 ± 0.050	0.00159 ± 0.00079	nd	nd	nd
Mali	10	10	1 ± 0.045	0.00915 ± 0.00219	-0.70120 (P > 0.10)	-0.73515 (P > 0.10)	-0.81915 (P > 0.10)
Laboratory lines	5	5	1 ± 0.126	0.01170 ± 0.00439	-0.29817 (P > 0.10)	-0.29817 (P > 0.10)	-0.31445 (P > 0.10)
Global population	168	105^b	0.757 ± 0.031	0.00777 ± 0.00066	-0.13448 (P > 0.10)	-2.05874 (P > 0.10)	-0.21350 (P > 0.10)

Abbreviations: n number of sequences, hd haplotype diversity index, π nucleotide diversity index, SD standard deviation, nd neutrality tests not determined as the minimum number of sequences required for neutrality tests is four
^aStatistical significance was deemed at a P-value of < 0.05
^bTotal number of GLURP subtypes in the global population is lower than the sum of GLURP subtypes in each population because some GLURP subtypes are detected in more than one population

ISSN: 1756-3305