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Fig. 6 | Parasites & Vectors

Fig. 6

From: P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells

Fig. 6

The proposed pathway of NLRP3 inflammasome activation in FHs 74 Int cells infected with T. gondii. P2X7R mediates activation of the NLRP3 inflammasome by forming a complex with the adaptor protein ASC and pro-Casp-1. Activation of the inflammasome induces IL-1β maturation and secretion. In addition, activation of the NLRP3 inflammasome inhibits T. gondii proliferation

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