From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease
Drug and AUC Target (μg·hr./mL) | Dose (mg/kg, twice daily, oral) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
0.625 | 1.25 | 1.875 | 2.5 | 3.75 | 5 | 6.25 | 7.5 | 8.75 | 10 | |
Doxycycline 22.8 | 4.1 | 45 | 79.37 | 91.5 | 99.5 | 99.9 | 100 | 100 | 100 | 100 |
Doxycycline 40.6 | 0.08 | 6.5 | 28 | 53.7 | 85 | 96.1 | 99.63 | 99.84 | 100 | 100 |
Minocycline 7.8 | 4 | 72 | 97.05 | 99.6 | 100 | 100 | 100 | 100 | 100 | 100 |
Minocycline 15 | 0 | 4.6 | 39.3 | 76 | 98.3 | 99.78 | 100 | 100 | 100 | 100 |