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Table 4 Probability of target attainment (PTA %) for doxycycline and minocycline at doses ranging from 0.625 to 10 mg/kg administered orally every 12 h to dogs

From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease

Drug and AUC Target (μg·hr./mL)

Dose (mg/kg, twice daily, oral)

 

0.625

1.25

1.875

2.5

3.75

5

6.25

7.5

8.75

10

Doxycycline 22.8

4.1

45

79.37

91.5

99.5

99.9

100

100

100

100

Doxycycline 40.6

0.08

6.5

28

53.7

85

96.1

99.63

99.84

100

100

Minocycline 7.8

4

72

97.05

99.6

100

100

100

100

100

100

Minocycline 15

0

4.6

39.3

76

98.3

99.78

100

100

100

100