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Table 3 Doxycycline and minocycline exposure in mice and humans after administration of standard doses in order to produce similar exposure relationships (AUC) in mice

From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease

 

100 mg dose

Human

200 mg dose

Human

Doxycycline

Minocycline

Doxycycline

Minocycline

AUC

μg·hr./mL

28.4

17.7

56.9

35.4

 

Mouse 25 mg/kg

once daily

Mouse 25 mg/kg

twice daily*

Doxycycline

Minocycline

Doxycycline

Minocycline

AUC

μg·hr./mL

22.8

7.8

40.6

14.9

Wolbachia reduction

66.3%

85%

90.35%

99.5%

  1. AUC area under the curve for doxycycline or minocycline exposure after standard dosages. *There were no significant changes in the level of Wolbachia depletion when comparing dose escalations between 25 and 80 mg/kg twice daily. Data from Sharma, et al. [9]