From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease
100 mg dose Human | 200 mg dose Human | |||
Doxycycline | Minocycline | Doxycycline | Minocycline | |
AUC μg·hr./mL | 28.4 | 17.7 | 56.9 | 35.4 |
Mouse 25 mg/kg once daily | Mouse 25 mg/kg twice daily* | |||
Doxycycline | Minocycline | Doxycycline | Minocycline | |
AUC μg·hr./mL | 22.8 | 7.8 | 40.6 | 14.9 |
Wolbachia reduction | 66.3% | 85% | 90.35% | 99.5% |