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Table 1 Minocycline and doxycycline pharmacokinetics in dogs

From: Considerations for using minocycline vs doxycycline for treatment of canine heartworm disease

Parameter

Doxycycline

Minocycline

Half-life (T-½) (hr)

12.6 (± 11)

5.18 (± 1.02)

VD/F (L/kg)

1.67 (± 0.81)

2.3 (± 0.59)

CL/F (L/kg/h)

0.13 (± 0.06)

0.28 (± 0.08)

Absorption (F)

61% (± 8)

50.3% (± 20.8)

Protein binding %

91–92%

65.8% (in vitro)

50% (in vivo)

  1. VD/F volume of distribution per fraction absorbed, CL/F clearance per fraction absorbed, F fraction absorbed. These parameters are presented as a weighted mean value to account for differences in the number of subjects in each study, as well as between-study and within-study variation [11,12,13,14,15]