Evaluation of cardiopulmonary and inflammatory markers in dogs with heartworm infection during treatment with the 2014 American Heartworm Society recommended treatment protocol

Yoon, Won-Kyoung; Kim, Ye-Won; Suh, Sang-I L; Choi, Ran; Lee, Seung-Gon; Hyun, Changbaig

doi:10.1186/s13071-017-2427-7

Table 1 Concentrations of serum biomarkers evaluated throughout the adulticide therapy in heartworm-infected dogs treated according to 2014 AHS guidelines. See Fig. 1 for time point (T) indicated in this table

From: Evaluation of cardiopulmonary and inflammatory markers in dogs with heartworm infection during treatment with the 2014 American Heartworm Society recommended treatment protocol

Markers		T-60	T0	T1	T7	T30	T31	T32	T39	T62	T92	T122	T182
cTnI	I (median)	.06	.07	.07	.04	.03^#	.03^#	.02^#	.02^#	.01^#	.02^#	.01^#	.01^#
	Min	.05	.03	.04	.03	.02	.01	.01	.01	.01	.01	.01	.01
	Max	.12	.09	.12	.06	.04	.05	.05	.02	.02	.03	.03	.04
	II (median)	.19^*	.17^*	.16^*	.08^*,#	.05^#	.05^#	.06^*,#	.03^#	.02^#	.01^#	.03^#	.02^#
	Min	.09	.07	.07	.03	.01	.03	.04	.01	.01	.01	.01	.01
	Max	.31	.21	.27	.13	.11	.13	.11	.11	.05	.02	.03	.03
	III (median)	.28^*	.26^*	.24^*#	.14^*#	.07^*,#	.07^*#	.06^*#	.03^#	.01^#	.03^#	.02^#	.01^#
	Min	.09	.09	1.0	.03	.05	.05	.05	.01	.01	.01	.00	.01
	Max	.59	.31	.33	.21	.09	.09	.09	.04	.03	.04	.04	.03
D-dimer	I (median)	.05	.00	.10	.03	.00	.09^#	.13^#	.00	.00	.00	.00	.00
	Min	.00	.00	.05	.00	.00	.00	.00	.00	.00	.00	.00	.00
	Max	.10	.05	.11	.10	.10	.21	.22	.05	.05	.05	.00	.00
	II (median)	.19^*	.14^*	.05^#	.14^*	.08^#	.16	.00	.11^*	.00^#	.00^#	.00^#	.00^#
	Min	.05	.09	.00	.12	.00	.15	.00	.00	.00	.00	.00	.00
	Max	.21	.16	.09	.17	.32	.24	.58	.19	.00	.09	.00	.00
	III (median)	.44^*	.38^*	.23^*	.08^*#	.00^#	.14^#	.15^#	.17^#	.00^#	.21^#	.06^#	.03^#
	Min	.35	.12	.00	.00	.00	.00	.07	.05	.00	.00	.00	.00
	Max	1.25	1.14	1.40	.30	.17	.18	.58	.38	.00	.27	.13	.14
CRP	I (median)	4	1	3	31^#	7	28^#	7	30^#	2	2	1	1
	Min	1	0	2	21	0	17	2	19	0	0	0	0
	Max	10	7	11	41	11	35	17	41	3	7	5	3
	II (median)	17^*	1	5	23	7	22	3	32	3	0^#	1^#	1^#
	Min	10	0	1	2	3	6	0	12	0	0	0	0
	Max	32	10	11	45	19	39	11	50	28	10	5	2
	III (median)	62^*	39^*	46^*	78^*#	36^*#	45	56^*	87^*#	30^*#	18^*#	16^*#	12^*#
	Min	33	35	18	54	24	23	34	40	14	0	0	2
	Max	101	75	87	121	56	72	100	123	58	45	31	21
IL-6	I (median)	28	17	28	39	17	46	44	45	18	25	19	12
	Min	9	12	11	23	5	5	29	17	9	15	5	8
	Max	35	21	44	72	37	63	49	54	23	33	34	31
	II (median)	65^*	48^*	57^*	111^*#	61^*	64^*	72^*	69^*	47^*#	35^#	35^#	23^#
	Min	51	26	21	49	32	39	26	45	19	32	21	14
	Max	94	67	123	250	86	83	102	102	54	62	45	27
	III (median)	93^*	41^*#	41^*#	192^*	110^*	90^*	139^*#	170^*#	57^*#	33^#	26^#	20^#
	Min	78	19	30	128	56	67	65	57	42	12	10	17
	Max	135	57	90	250	250	250	250	250	98	56	66	31

Abbreviations: cTnI cardiac troponin I, CRP C-reactive protein, IL-6 interleukin 6
*P < 0.05 class I to class II and III
^# P < 0.05 baseline value (T-60) to each time point

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ISSN: 1756-3305

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