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Table 5 Owner assessment of pruritus using a visual analogue scale (PVAS) for dogs naturally infested with fleas and administered either Sarolaner or Spinosad treatments

From: Evaluation of sarolaner and spinosad oral treatments to eliminate fleas, reduce dermatologic lesions and minimize pruritus in naturally infested dogs in west Central Florida, USA

Treatment group

 

Days post-treatmenta

 

Day 0

Day 7

Day 14

Day 28–30

Day 42–45

Day 56–60

Sarolanerb

# Dogs

28

28

28

28

28

27

Mean PVAS Scored

7.30

2.76

2.43

2.25

1.25

0.83

SD

2.22

2.67

2.39

2.23

1.73

1.15

Range

1.3–10.0

0–9.8

0.2–9.5

0–6.5

0–7.8

0–4.1

Reduction (%)e

 

62.23

66.68

69.18

82.88

88.64

# (%) ≤ 1.9

2 (7.14%)

13 (46.43%)

16 (57.14%)

13 (46.43%)

21 (75.0%)

23 (85.19%)

Spinosadc

# Dogs

25

25

24

25

25

23

Mean PVAS Scored

7.43

3.23

2.69

2.85

1.58

1.07

SD

1.61

2.21

2.50

2.40

1.79

1.75

Range

3.7–10.0

0.1–7.6

0–9.5

0–8.8

0–7.8

0–7.3

Reduction (%)e

 

56.54

63.76

61.66

78.73

85.60

# (%) ≤ 1.9

0 (0.0%)

8 (32.00%)

13 (54.17%)

11 (44.00%)

21 (84.0%)

20 (85.60%)

  1. Abbreviation: SD standard deviation
  2. No significant differences between the two groups were observed, for any day, based on the repeated measures analysis (P = 0.6942)
  3. aIn both groups, dogs were treated on day 0 and once between days 56 – 60
  4. bDogs were orally administered Sarolaner chewables (Simparica® Zoetis) according to label directions
  5. cDogs were orally administered Spinosad flavored tablets (Comfortis® Elanco) according to label directions
  6. dArithmetic mean pruritus score as assessed by dog owners using the PVAS [31]
  7. e{(Day 0 arithmetic mean PVASscore – day x arithmetic mean PVAS score)/day 0 arithmetic mean PVAS score)} × 100