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Table 4 Assessment of skin lesions using the Canine Atopic Dermatitis Extent and Severity Index-4 (CADESI-4) scale for dogs naturally infested with fleas and administered either Sarolaner or Spinosad oral treatments

From: Evaluation of sarolaner and spinosad oral treatments to eliminate fleas, reduce dermatologic lesions and minimize pruritus in naturally infested dogs in west Central Florida, USA

Treatment group

 

Days post-treatmenta

Day 0

Day 28–30

Day 54-60

Sarolanerb

# Dogs

29

29

28

Mean CADESI - 4 Scored

35.41

17.62

11.54

SD

22.79

16.21

9.78

Range

4–94

0–71

0–39

Reduction (%)e

 

50.24

67.43

Spinosadc

# Dogs

26

26

25

Mean CADESI - 4 Scored

32.65

16.58

12.28

SD

20.50

13.43

9.60

Range

1–91

1–58

3–43

Reduction (%)e

 

49.23

62.39

  1. Abbreviation: SD standard deviation
  2. No significant differences between the two groups were observed, for any day, based on the repeated measures analysis (P = 0.8588)
  3. aIn both groups, dogs were treated on day 0 and once between days 56–60
  4. bDogs were orally administered Sarolaner chewables (Simparica® Zoetis) according to label directions
  5. cDogs were orally administered Spinosad flavored tablets (Comfortis® Elanco) according to label directions
  6. dArithmetic mean Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4 scores [34]
  7. e{(Day 0 arithmetic mean CADESI-4 score – day x arithmetic mean CADESI-4 score) / day 0 arithmetic mean CADESI-4 score)} × 100
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