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Table 4 Flea counts, ranges of counts and mean efficacy at each time point for primary dogs in two clinical field studies in the northern and southern regions of Australia

From: Efficacy and safety of sarolaner (Simparica®) in the treatment and control of naturally occurring flea infestations in dogs presented as veterinary patients in Australia

Day of study

Northern study

Southern study

Sarolaner

(2–4 mg/kg)

Spinosad

(≥ 30 mg/kg)

Sarolaner

(2–4 mg/kg)

Spinosad

(≥ 30 mg/kg)

Day 0

 No. of animals

34

19

33

18

 Arithmetic mean count

39.5

127.9

27.6

47.8

 Range of counts

7–288

5–772

5–119

5–156

Day 14

 No. of animals

34

19

31

16

 Arithmetic mean count

0.4

3.9

1.1

2.3

 Range of counts

0–7

0–32

0–18

0–28

 Mean efficacy (%)a

99.3

94.6

96.7

97.6

 Range of efficacy (%)a

83–100

72–100

50–100

82–100

Day 30

 No. of animals

32

18

29

18

 Arithmetic mean count

0

7.9

0.2

10.7

 Range of counts

0–1

0–103

0–3

0–130

 Mean efficacy (%)a

99.2

95.7

99.5

89.7

 Range of efficacy (%)a

90–100

73–100

96–100

0–100

Day 60

 No. of animals

30

18

27

16

 Arithmetic mean count

0

0

0.1

0

 Range of counts

0–1

0–0

0–2

0–0

 Mean efficacy (%)a

98.8

100

98.6

100

 Range of efficacy (%)a

92–100

100–100

60–100

100–100

Day 90

 No. of animals

29

15

23

16

 Arithmetic mean count

0

0

0

0.4

 Range of counts

0–0

0–0

0–0

0–4

 Mean efficacy (%)a

99.9

100

100

99.3

 Range of efficacy (%)a

100–100

100–100

100–100

92–100

  1. aEfficacy calculated for each animal as the percentage reduction in flea count compared to Day 0
  2. Note: In both studies, there was no significant evidence of an overall difference between treatment groups, with non-significant terms for the treatment group main effect and the treatment by time interaction term in the repeated measures models (P > 0.14 in all cases). Therefore, comparisons between the treatment groups at each time point have not been presented