No. of hamsters cured/treated | Mean no. of alive worms ± SD | WBR (%) | Female WBR (%) | ED50 (mg/kg) | |||||
---|---|---|---|---|---|---|---|---|---|
Liver | Mesenteric veins | Total | Females | ||||||
Control | 0/4 | 2.75 ± 3.8 | 31.0 ± 9.5 | 33.8 ± 16.8 | 15.3 ± 5.2 | – | – | – | |
PZQ | |||||||||
250.0 mg/kg | 3/4 | 0.25 ± 0.5 | 0 | 0.3 ± 0.5 | 0 | 99.3 | 100 | ||
200.0 mg/kgb | 77.2 | 118.1 | |||||||
150.0 mg/kgb | 66.1 | ||||||||
100.0 mg/kgb | 39.2 | ||||||||
R-PZQ | |||||||||
125.0 mg/kg | 2/4 | 0.25 ± 0.5 | 0.25 ± 0.5 | 0.5 ± 0.6 | 0 | 98.5 | 100 | 24.7a | |
62.5 mg/kg | 1/4 | 5.0 ± 4.7 | 3.25 ± 3.6 | 8.3 ± 8.1 | 2.3 ± 3.3 | 75.6 | 85.2 | ||
31.0 mg/kg | 0/3 | 6.7 ± 11.5 | 2.3 ± 2.3 | 9.0 ± 13.9 | 4.0 ± 6.9 | 73.3 | 73.8 | ||
S-PZQ | |||||||||
500.0 mg/kg | 3/4 | 1.25 ± 2.5 | 0.75 ± 1.5 | 2.0 ± 4.0 | 0 | 94.1 | 100 | 127.6a | 5.17c |
250.0 mg/kg | 2/4 | 4.0 ± 4.9 | 1.75 ± 2.1 | 5.8 ± 6.9 | 0 | 83.0 | 100 | ||
125.0 mg/kg | 0/3 | 7.0 ± 6.2 | 11.0 ± 6.0 | 18.0 ± 12.1 | 0.7 ± 0.6 | 46.7 | 95.6 |