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Table 1 IC50 and IC90 values of PZQ, R-PZQ, S-PZQ enantiomers and trans-4-OH-PZQ against adult worms of S. haematobium

From: In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium

 

IC50 at 4 h (μg/ml)

r-value

IC50 at 72 h (μg/ml)

r-value

IC90 at 72 h (μg/ml)

r-value

Eudysmic ratio

PZQ

0.03

0.978

0.03

0.965

0.09

0.978

501

R-PZQ

0.007

0.803

0.01

0.940

0.03

0.940

 

S-PZQ

3.51

0.925

3.40

0.923

5.98

0.923

Trans-4-OH-PZQ

1.47

0.891

1.47

0.891

3.31

0.891

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Parasites & Vectors

ISSN: 1756-3305

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