Fig. 4From: The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis The levels of enzymes involved in the tick hemoglobinolytic pathway vary in a tissue-specific manner in response to A. phagocytophilum infection. Differential expression/representation of tick hemoglobinolytic enzymes in response to A. phagocytophilum infection was obtained from Ayllón et al. [12] and represented by pondering mRNA (transcriptomics RNAseq and real-time RT-PCR) and protein (proteomics) data. In tick midguts, the hemoglobinolytic pathway operating in the endosomal digestive vesicle was revised by Sojka et al. [19]. In tick salivary glands, these enzymes are also produced and may function under different conditions. Abbreviations: AMP, hemoglobin-derived antimicrobial peptides (Hemocidins and other); HRG1, Heme-responsive gene 1; HELP, Heme-binding lipoprotein; VG1, Vitellogenin 1; VG2, Vitellogenin 2Back to article page