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Table 4 Major clusters of T. brucei specific proteins identified in this study

From: A proteomics approach reveals molecular manipulators of distinct cellular processes in the salivary glands of Glossina m. morsitans in response to Trypanosoma b. brucei infections

Protein family

UniProt ID

Protein name

Functional roles

Variant/invariant surface glycoproteins (VSG/ISG)

Q26842

VSG

VSGs/ISGs are activated in the SGs; involved in immune evasion/resistance

M4TB38

VSG 1228

M4SU87

VSG 725

Q57VX7

75 kDa ISG

B2ZWC6

ISG

Retrotransposon hot spot protein (RHS) multigene family

Q8T9M3

RHS1a

RHSs are diverse and potentially rapidly evolving nuclear and perinuclear proteins in T. brucei. RHSs are located in the polymorphic subtelomic regions and may therefore confer selective advantages for the evasion of host immune responses through antigenic variations

Q8T9M7

RHS2a

Q8WPS8

H25N7.12 protein (RHS4)

Q8T9M4

RHS6a

D0A6L8

Putative RHS

D7SGA2

RHS4

Q584N8

Putative RHS

Q585G9

RHS5a

Kinetoplastid calpain/small kinetoplastid calpain-related protein (CALP/SKCRP) protein family

Q4GZ11

CALP1.1

CALPs are well-conserved and ubiquitously expressed in tissue-specific isoforms. They are involved in virulence and various physiological (cytoskeleton rearrangement, proliferation, cellular differentiation, interaction with host structures)

C9ZIE8

CALP1.2

Q57WJ7

CALP5.5 V

C9ZT01

CALP7.1

Q387E1

CALP11.6

Q4GZ06

SKCRP1.4

C9ZIF2

SKCRP1.5

C9ZIF6

SKCRP1.7

Paraflagellar/paraxial rod (PRF) protein family

C9ZVV0

69 kDa PFR-A

69-kDa and 73-kDa proteins are the major structural components of T. brucei flagellar; Important for parasite motility

C9ZLC1

73 kDa PFR-C

Peroxiredoxin alkyl hydroperoxide reductase C (AhpC)-type family

C9ZL57

Tryparedoxin

TXN/TXNPx are highly abundant in all life stages of T. brucei; Important in trypanosome metabolism (nucleotide synthesis); and oxidative defence (detoxification of hyperoxides)

C9ZUX7

Tryparedoxin peroxidase

C9ZXT5

Tryparedoxin peroxidase

Bloodstream stage alanine-rich protein (BARP)

C9ZZP8

BARP

BARPs are GPI-anchored proteins, which are important for cytokinesis; BARPs are proposed to form stage-specific coat for epimastigote forms of T. brucei

O60946

BARP

Q38CW0

BARP

Q38CW1

BARP

C9ZZQ0

BARP

Molecular chaperones; heat shock proteins (Hsp) family

C9ZL02

Putative Hsp20

Molecular chaperones are central players in various physiological processes such as protein folding and in maintenance of cellular homeostasis/survival under optimal growth conditions

D0A349

Mitochondrial Hsp60

C9ZR44

Mitochondrial Hsp70

Q383E5

Hsp70

D0A4N5

Hsp83

D0A590

Putative Hsp

Membrane transporters

Q388Z2

Plasma membrane ATPase (PMA1)

Involved in salvage of nutrients and other metabolites from the host

C9ZK10

ATP synthase subunit beta (ATP5B)

Q581D7

Putative adenosine transporter 1 (ENT1)

Ribosomal proteins (RPs)

D0A7E1

RPS5

Involved in the regulation of protein translation

C9ZXI9

RPS7

O76223

RPS12

C9ZRH0

RPS14

D0A2S1

RPS18

C9ZZX2

RPL10a

C9ZYV4

RPL23

  1. Functional roles were inferred from available literature. Only a selection of variant/invariant surface glycoproteins (VSGs/ISGs) is shown in this table (see full list of the isoforms and/or variants in Additional file 1: Table S3)