Effects of transmission-blocking vaccines simultaneously targeting pre- and post-fertilization antigens in the rodent malaria parasite Plasmodium yoelii

Table 2 Transmission-blocking effect anti-Pys25 and Pys48/45 sera in direct mosquito feeding assay

	Vector control	Pys25	Pys48	Pys25 + Pys48
N	26	27	28	28
# not infected	0	11	8	4
Prevalence (%)^a	100.0	59.3	71.4	85.7
Median	221.0	3.0	23.5	18.5
Mean	224.6	3.6	26.4	24.9
Range	420	14	75	71
Reduction in Oocyst (%)^b	na	98.6	89.4	91.6
Reduction in Prevalence (%)^c	na	40.7	28.6	14.3

^aThe prevalence of infection was calculated by number of mosquitoes with oocysts/total mosquitoes dissected in each group
^b% reduction in oocyst was calculated as (median_control–median_{pcDNA3.1 + plasmid})/median_control × 100
^c% reduction in prevalence was calculated as (% prevalence_control–% prevalence_{pcDNA3.1 + plasmid})/ % prevalence_control × 100

ISSN: 1756-3305