Table 2 Mean (arithmetic) plasma pharmacokinetic parameters for fluralaner in cats following single topical and i.v. administration

C_max (ng/ml)

757 ± 328

1850 ± 808

2399 ± 865

4302 ± 435

t_max ^a (day)

9 (range 5–10)

6 (range 3–14)

9 (range 7–21)

n/a

AUC_(0→t) (day*ng/ml)

22065 ± 7996

48161 ± 15294

89193 ± 21413

21863 ± 2160

AUC_(0→∞) (day*ng/ml)

22276 ± 7996

48400 ± 15177

89690 ± 21479

22141 ± 2105

t_1/2 (day)

13 ± 2

12 ± 4

12 ± 1

11 ± 1

t_last (day)

93 ± 14

102 ± 12

110 ± 6

68 ± 7

MRT (day)

24 ± 3

23 ± 7

29 ± 5

15 ± 1

Cl (L/kg/day)

n/a

n/a

n/a

0.23 ± 0.02

V_z (L/kg)

n/a

n/a

n/a

3.5 ± 0.5

F (%)

25 ± 9

28 ± 9

25 ± 6

n/a