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Table 1 Vaccines used for leishmaniasis

From: Possibilities and challenges for developing a successful vaccine for leishmaniasis

Antigen

Disease

Vaccine type

Animal model

Result/Outcome

Reference No. (year)

Centrin deleted live parasite L. donovani

VL

Live (Genetically modified)

Dogs

Protection

[76] (2015)

Ascorbic acid-deficient live mutants of L. donovani

VL

Live (Genetically modified)

Mouse

Protection

[77] (2015)

Leishmania parasites lacking essential genes like dyhydrofolate reductase, biopterin reductase and cystein proteases

CL (L. max)

Live (Genetically modified)

Mouse

Partial protection

[79] (2015)

CL (L. m.)

p27 gene knockout L. donovani parasites

VL (L. d.)

Live attenuated

Mouse

Protection

[82] (2013)

L. major (ALM) + BCG

VL & PKDL

Killed vaccine

Mouse

Partial protection

[5] (2006)

KBMA L. infantum and L. chagasi

VL

Killed vaccine

Mouse

Partial protection

[86] (2012)

Leishmune (FML)

VL (L. d.)

Fractioned vaccine

Dogs

Partial protection

[88] (2006)

KMP 11

CL (L. m.)

Recombinant vaccine

Hamster

Protection

[94] (2005)

Leish F1

VL (L. d.)

Recombinant protein

Clinical trial

Protection

[92, 93] (2011)

Leish 111f

VL (L. d.)

Recombinant vaccine

Mouse

Protection

[99] (2007)

HASPB1

VL (L. d.)

Recombinant protein

Mouse

Partial protection

[95] (2000)

Leish-f1+MPL-SE

VL (L. I)

Recombinant vaccine

Clinical trial

Protection

[93] (2011)

rSMT

VL (L. d.)

Recombinant vaccine

Mouse

Protection

[102] (2007)

A2

VL (L. i.)

Recombinant vaccine

Mouse

Partial protection

[101] (2009)

Leish-110f

VL (L. i)

Recombinant vaccine

Mouse

Protection

[98] (2009)

LD91+LD72+ LD51+LD31

VL (L.d.)

Antigen cocktail vaccine

Mouse

Partial protection

[109] (2009)

(P-8 PGLC)

L. pifanoi

Antigen cocktail vaccine

Dog

Partial protection

[110] (2007)

rCDV-LACK, rCDV-TSA, and rCDV-LmSTI1

CL (L. m.)

Antigen cocktail vaccine

Dog

Protection

[113] (2015)

Gp63

VL (L.d.)

DNA vaccine

Mouse

Partial protection

[119] (2011)

TRYP

VL (L. i.)

DNA vaccine

Dog

Protection

[121] (2009)

NH36

VL (L. d.)

DNA vaccine

Mouse

Partial protection

[123] (2009)

Proteophosphoglycans (PPGs)

VL (L. d.)

DNA vaccine

Hamster

Partial protection

[124] (2009)

ORFF

VL (L. d.)

DNA vaccine

Mouse

Partial protection

[127] (2009)

LPG 3

VL (L. i.)

DNA vaccine

Mouse

Partial protection

[128] (2014)

LEISHDNAVAX

VL (L. i.)

DNA vaccine

Mouse

Protection

[130] (2015)

  1. Abbreviations: VL Visceral Leishmaniasis, CL Cutaneous Leishmaniasis, PKDL Post kala-azar dermal leishmaniasis, L.d. L. donovani, L.i., L. infantum, L.m. L.major, L.max, L. maxicana