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Fig. 1 | Parasites & Vectors

Fig. 1

From: Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole

Fig. 1

Antipromastigote activity of imipramine, miconazole and their combination. Promastigotes of L. amazonensis were incubated with different concentrations of imipramine with or without miconazole for 72Ā hours at 26Ā Ā°C. a imipramine, b imipramineā€‰+ā€‰miconazole c an isobologram. Each plotted point in the isobologram is the IC50 of the drugs alone or in combination. The straight line connecting the individual IC50values represents the theoretical line of additivity. The experiments were performed in triplicate, nā€‰=ā€‰3. The graphs are representative of one experiment, and the standard deviations are shown. The graphics and IC50 values were obtained using the GraphPad Prism 4 software. * Pā€‰<ā€‰0.05, ** Pā€‰<ā€‰0.01, *** P <0.001

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