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Table 2 Comparison of the numbers of ion channel sequences within each family among humans, C. elegans and representative parasitic flatworms* that were classified with high and medium confidence

From: Pipeline for the identification and classification of ion channels in parasitic flatworms

Ion channel family

Hs

Ce

Trematoda

Cestoda

Ov

Cs

Sh

Sj

Sm

Eg

Em

Ts

Cys-loop superfamily

46

36

3

2

4

5

4

6

6

7

Glutamate-gated cation channels

18

8

4

6

6

0

4

5

5

5

Epithelial and related channels

16

0

3

2

1

3

4

2

2

3

Ryanodine and IP3 receptors

6

2

1

1

1

1

2

1

1

0

Voltage-gated ion channels

114

22

16

15

14

11

16

12

13

7

Related to voltage-gated ion channels

66

14

10

13

9

6

12

9

8

7

Chloride channels

19

7

2

2

2

3

3

3

3

1

Aquaporins

14

4

2

3

1

2

2

0

0

0

Unclassified ion channel-like proteins

-

-

73

54

69

88

40

38

44

65

Total

299

93

114

98

107

119

87

82

82

95

  1. *Hs Homo sapiens, Ce Caenorhabditis elegans, Ov Opisthorchis viverrini, Cs Clonorchis sinensis, Sh Schistosoma haematobium, Sj Schistosoma japonicum, Sm Schistosoma mansoni, Eg Echinococcus granulosus, Em Echinococcus multilocularis, Ts Taenia solium