Table 2 Inoculation route and parasite dose influences on visceral leishmaniasis outcome in susceptible BALB/c mice
From: Study of Leishmania pathogenesis in mice: experimental considerations
Infection route | Parasite dose | Parasite strain | Liver load | Spleen load | Th1 response | Th2 response | Reference |
|---|---|---|---|---|---|---|---|
Subcutaneous | 105 | LIVT-1 | + | - | ND | ND | [32] |
106 | + | + | ND | ND | |||
107 | + | + | ND | ND | |||
| Â | 103 | MHOM/BR/1970/BH46 | +/- | ++ | + | + | [33] |
105 | + | +++ | + | + | |||
107 | ++ | ++++ | + | +++ | |||
| Â | 103 | MHOM/IN/80/DD8 | +/- | ND | +++ | + | [34] |
105 | + | ND | ++ | + | |||
107 | + | ND | ++ | ++ | |||
Intradermal | 103 | MHOM/IN/80/DD8 | + | ND | +++ | + | [34] |
105 | ++ | ND | ++ | + | |||
107 | ++ | ND | ++ | + | |||
| Â | 107 | MHOM/ES/92/LLM-320 | +++ | +++ | + | + | [38] |
Intraperitoneal | 103 | MHOM/IN/80/DD8 | ++ | ND | ++ | ++ | [34] |
105 | +++ | ND | + | ++ | |||
107 | +++ | ND | + | +++ | |||
| Â | 107 | MCAN/PT/94/IMT205 | ND | + | ND | ND | [37] |
Intracardiac | 103 | MHOM/IN/80/DD8 | ++ | ND | ++ | ++ | [34] |
105 | +++ | ND | + | ++ | |||
107 | ++++ | ND | - | +++ | |||
| Â | 107 | MHOM/IN/1993/B12302 | +++ | ++ | ++ | ++ | [35] |
Intravenous | 105 | LIVT-1 | + | + | ND | ND | [32] |
106 | ++ | + | ND | ND | |||
107 | +++ | + | ND | ND | |||
| Â | 107 | MHOM/BR/1970/BH46 | + | + | + | ++ | [33] |
| Â | 103 | MCAN/ES/96/BCN150 | + | + | +/- | - | [36] |
105 | ++ | ++ | +/- | +/- | |||
106 | ++ | +++ | + | ++ | |||
| Â | 104 | MHOM/ES/92/LLM-320 | +/- | + | ND | ND | [38] |
105 | + | ++ | ND | ND | |||
106 | ++ | +++ | ND | ND | |||
| Â | 107 | MCAN/PT/94/IMT205 | ND | + | ND | ND | [37] |