Trichuris trichiura | |||||
---|---|---|---|---|---|
 | Weeks post-treatment | Albendazole – ivermectin (n = 100) | Albendazole – mebendazole (n = 101) | Albendazole – oxantel pamoate (n = 100) | Mebendazole (n = 104) |
Children positive before treatment (%) | 100 (100) | 101 (100) | 100 (100) | 104 (100) | |
No. of children cured (CR, 95 % CI) | 3 weeks | 28 (28.0, 19.5–37.9, p < 0.001)* | 9 (8.9, 4.2–16.2, p < 0.001)* | 68 (68.0, 57.9–77.0) | 8 (7.7, 3.4–14.6, p < 0.001)* |
No. of children negative (extended CR, 95 % CI) | 18 weeks | 20 (20.0, 12.7–29.2, p < 0.001)* | 14 (13.9, 7.8–22.2, p < 0.001)* | 54 (54.0, 43.7–64.0) | 11 (10.6, 5.4–18.1, p < 0.001)* |
Geometric mean: EPG | Baseline | 489.9 | 390.0 | 471.3 | 467.8 |
3Â weeks | 25.0 | 176.0 | 3.7 | 207.8 | |
18Â weeks | 47.8 | 128.1 | 6.6 | 158.8 | |
ERR (95 % CI) | 3 weeks | 94.9 (92.3–96.7) | 54.9 (38.3–67.7) | 99.2 (98.6–99.6)a | 55.6 (40.0–68.0) |
Extended ERR (95 % CI) | 18 weeks | 90.2 (85.3–93.6) | 67.2 (51.9–77.9) | 98.6 (97.8–99.2)a | 66.1 (52.0–76.6) |
No. of children positive (prevalence, 95 % CI) | Baseline | 100 (100, −) | 101 (100, −) | 100 (100, −) | 104 (100, −) |
3 weeks | 72 (72.0, 62.1–80.5) | 92 (91.1, 83.8–95.8) | 32 (32.0, 23.0–42.1) | 96 (92.3, 85.4–96.6) | |
18 weeks | 80 (80.0, 70.8–87.3) | 87 (86.1, 77.8–92.2) | 46 (46.0, 36.0–56.3) | 93 (89.4, 81.9–94.6) | |
Reinfections (%, 95 % CI) | 18 weeks | 15/28 (53.6, 33.9–72.5) | 2/9 (22.2, 2.8–60.0) | 21/68 (30.9, 20.2–43.6) | 4/8 (50.0, 15.7–84.3) |