Table 2 Changes (least square means values) in APP and oxidative markers and change rates detected during post-vaccination and post-challenge periods

CRP (μg/mL)

vaccination

1

6.9 (4.5)

70.6 (11.52)

24

10.23

2

5 (0)

8.65 (10.66)

13

1.73

challenge

1

5 (0)

112 (23.31)

22

22.4

2

5 (0)

173 (23.31)

22

34.6

3

5 (0)

252 (23.31)

14

50.4

Hp (g/L)

vaccination

1

1.68 (1.62)

5.04 (0.73)

24

3

2

0.28 (0.23)

1.88 (0.69)

24

6.7

challenge

1

1.56 (0.16)

4.86 (1.21)

22

3.11

2

1.77 (1.17)

3.78 (1.05)

22

2.13

3

2.13 (0.29)

8.60 (1.05)

14

4.03

SAA (μg/mL)

vaccination

1

5.1 (2.39)

23.94 (2.9)

24

4.69

2

3.43 (1.92)

5.1 (2.5)

13

1.48

challenge

1

1.43 (0.97)

61 (9.9)

22

42.65

2

2.05 (1.29)

36 (8.6)

22

17.56

3

1.66 (0.43)

156.77 (8.6)

14

94.43

Albumin (g/dL)

vaccination

1

3.07 (0.06)

2.33 (0.26)

31

0.75

2

3 (0.31)

3.01 (0.29)

31

1

challenge

1

3.64 (0.4)

2.8 (0.15)

22

0.76

2

3.99 (0.24)

2.8 (0.15)

22

0.7

3

3.79 (0.19)

1.64 (0.17)

22

0.43

TAC (mmol/L)

vaccination

1

0.36 (0.16)

0.07 (0.06)

31

0.19

2

0.45 (0.017)

0.04 (0.06)

39

0.08

challenge

1

0.36 (0.06)

0.12 (0.08)

22

0.33

2

0.46 (0.1)

0.2 (0.06)

14

0.43

3

0.24 (0.13)

0.08 (0.03)

14

0.33

PON-1 (IU/mL)

vaccination

1

2.91 (0.27)

2.1 (0.16)

31

0.72

2

2.43 (0.29)

2.2 (0.16)

38

0.9

challenge

1

3.64 (0.6)

2.1 (0.23)

22

0.57

2

3.9 (0.68)

2.05 (0.23)

22

0.52

3

3.62 (0.11)

1.3 (0.23)

22

0.35