Figure 8
From: A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis
Macrofilaricidal activity of parenteral FBZ against Onchocerca macrofilariae in SCID mice. Percentage recoveries +5 weeks after intraperitoneal surgical implantation of 15 isolated, motile male Onchocerca macrofilariae in BALB/c SCID mice and commencement of a 5 day 10 mg/kg qd sub-cutaneous dosing with flubendazole (FBZ) or matching vehicle control (VC). Error bars indicate median and interquartile range. Data is from an individual experiment (n = 7-8/group). Significant differences between groups (Mann Whitney Test) are indicated **P < 0.01.