Figure 3

Comparative macrofilaricidal activity of FBZ against Brugia in WT versus SCID mice. (A) % recoveries of Bm macrofilariae and (B) numbers of granulomas recovered +6 weeks after intraperitoneal surgical implantation into BALB/c WT or BALB/c SCID mice and commencement of a 5 day 10 mg/kg qd sub-cutaneous dosing with flubendazole (FBZ) or matching vehicle control (VC). Error bars indicate median and interquartile range. Data is from an individual experiment (n = 5/group). Significant differences between groups (Mann Whitney Test) are indicated *P < 0.05, **P < 0.01.