Table 2 Effect on worm burden of single oral doses of three selected organometallic CQ derivatives administered to mice harboring a 49-day-old adult S. mansoni infection, stratified by sex and worm distribution
From: In vitro and in vivo antischistosomal activity of ferroquine derivatives
Drug | Dose (mg/kg) | No. of mice investigated | No. of mice cured | Mean number of worms (SD) | Total worm burden reduction (%) | p-value | Female worm burden reduction (%) | p-value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Liver | Mesenteric veins | Total | Males | Females | ||||||||
Control1 | - | 8 | - | 0.4 (0.7) | 33.8 (10.2) | 34.1 (10.3) | 19.9 (7.7) | 14.3 (4.2) | - | - | - | - |
Control2 | - | 8 | - | 0.6 (1.2) | 25.8 (16.7) | 26.4 (16.7) | 14.5 (9.3) | 11.9 (7.7) | - | - | - | - |
FQa | 200 | 4 | 0 | 1.8 (2.4) | 25.8 (7.3) | 27.5 (7.3) | 16.3 (4.9) | 11.3 (4.0) | 19.4 | >0.05 | 21.0 | >0.05 |
FQb | 800 | 4* | 0 | 0.7 (1.2) | 16.3 (4.2) | 17.0 (5.3) | 10.3 (5.8) | 6.7 (1.2) | 35.6 | >0.05 | 43.7 | 0.018 |
FQ-OHa,b | 200 | 3 | 0 | 3.7 (5.5) | 21.3 (26.6) | 25.0 (24.4) | 16.3 (14.3) | 8.7 (10.8) | 17.3 | >0.05 | 33.6 | >0.05 |
RQa | 200 | 4 | 0 | 0.25 (0.5) | 36.5 (10.7) | 36.8 (10.4) | 18.8 (5.3) | 18.0 (5.3) | 0 | >0.05 | 0 | >0.05 |
MQ | 200 | 5 | 0 | 72.3 [8] | 100 | |||||||
CQ | 200 | 5 | 0 | 11.7 [8] | 93.0 | |||||||