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Table 3 Effect of albendazole, nitazoxanide, sequentially administered albendazole-nitazoxanide combination, and placebo against intestinal protozoa infections among school-aged children on Pemba Island in mid-2011

From: Prevalence of intestinal protozoa infection among school-aged children on Pemba Island, Tanzania, and effect of single-dose albendazole, nitazoxanide and albendazole-nitazoxanide

Characteristic

Single-dose albendazole

Single-dose nitazoxanide

Nitazoxanide-albendazole combination

Placebo

G. intestinalis

No. of infected children

25

21

19

25

No. of children not cured after treatment

10

9

11

12

CR, % (95% CI)

60.0

57.1

42.1

52.0

 

(39.4–80.6)

(34.1–80.2)

(17.7–66.6)

(31.0–73.0)

E. histolytica/E. dispar

No. of infected children

23

23

31

22

No. of children not cured after treatment

10

9

10

10

CR, % (95% CI)

56.5

60.9

67.7

54.5

 

(34.6–78.4)

(39.3–82.4)

(50.3–85.2)

(31.9–77.1)

B. hominis

No. of infected children

35

37

33

49

No. of children not cured after treatment

15

16

10

16

CR, % (95% CI)

57.1

56.8

69.7

67.3

 

(39.9–74.4)

(40.0–73.5)

(53.1–86.2)

(53.7–81.0)

E. coli

No. of infected children

75

82

56

70

No. of children not cured after treatment

50

38

27

50

CR, % (95% CI)

33.3

53.7

51.8

28.6

 

(22.4–44.3)

(42.6–64.7)

(38.3–65.3)

(17.7–39.4)

E. hartmanni

No. of infected children

14

22

18

19

No. of children not cured after treatment

5

5

4

7

CR, % (95% CI)

64.3

77.3

77.8

63.2

 

(35.6–93.0)

(58.3–96.3)

(56.5–99.1)

(39.3–87.0)

E. nana

No. of infected children

24

25

23

35

No. of children not cured after treatment

10

9

2

15

CR, % (95% CI)

58.3

64.0

91.3

57.1

 

(37.1–79.6)

(43.8–84.2)

(78.8–100.0)

(39.9–74.4)

C. mesnili

No. of infected children

17

10

6

12

No. of children not cured after treatment

4

1

1

5

CR, % (95% CI)

76.5

90.0

83.3

58.3

 

(54.0–99.0)

(67.4–100.0)

(40.5–100.0)

(25.6–91.1)

I. bütschlii

No. of infected children

5

13

8

11

No. of children not cured after treatment

1

2

2

4

CR, % (95% CI)

80.0

84.6

75.0

63.6

 

(24.5–100.0)

(61.9–100.0)

(36.3–100.0)

(29.7–97.5)

  1. CI, confidence interval; CR, cure rate.