Location   (Study year) | Participants | Treatment arms | Mosquitoes (numbers used) | Mosquito infection method | Ref. |
---|---|---|---|---|---|
Gambia* (2000) | Children (1–9 yrs) | Artesunate [a] + chloroquine [b]; chloroquine [b] | Anopheles gambiae (1208) | Membrane feeding | [15] |
Gambia (1999) | Children | Artesunate [a] + sulfadoxine-pyrimethamine [f]; sulfadoxine-pyrimethamine [f] | Anopheles gambiae (3192) | Membrane feeding | [16] |
Gambia (1998) | Children | Artesuante [g] + sulfadoxine-pyrimethamine [f]; sulfadoxine-pyrimethamine [f] | Anopheles gambiae (2688) | Membrane feeding | [16] |
Kenya (2003–4) | Children (6 months–10 yrs) | Sulfadoxine-pyrimethamine [h] + placebo [i]; artesunate [a] + sulfadoxine-pyrimethamine [h]; sulfadoxine-pyrimethamine [h] + Amodiaquine [j]; artemether-lumefantrine [k] | Anopheles gambiae (3000) | Membrane feeding | [17] |
Gambia (2002) | Children (1-10Â yrs) | Artemether-lumefantrine [c]; chloroquine[d] + sulfadoxine-pyrimethamine [e] | Anopheles gambiae (540) | Membrane feeding | [18] |
USA** | Adults | Primaquine [l]; Sulfadiazine + pyrimethamine [m] | Anopheles stephensi (30) | Direct skin bite | [19] |
USA*** (1968) | Adults (25 to 41Â yrs) | Primaquine [l]; pyrimethamine [n] | Anopheles stephensi (163) | Direct skin bite | [20] |