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Table 1 Mean (± SEM) body weight, weight of spleen and weight of the liver of BALB/c mice infected with L. major , S. mansoni and those co-infected with L. major + S. mansoni

From: Combination therapy using Pentostam and Praziquantel improves lesion healing and parasite resolution in BALB/c mice co-infected with Leishmania major and Schistosoma mansoni

Parasite infection

 

Body weights (g)

Weight of spleen (g)

Weight of the liver (g)

Treatments

Week 8

Week 10

% change

Week 8

Week 10

% change

Week 8

Week 10

% change

L. major

P

18.2 ± 0.8

20.4 ± 1.4

12.1

0.14 ± 0.007

0.15 ± 0.012

7.14

0.81 ± 0.091

0.80 ± 0.084

−1.26

PZQ

18.0 ± 0.5

16.6 ± 1.4

−7.77

0.20 ± 0.027

0.24 ± 0.009

20.00

0.84 ± 0.014

0.86 ± 0.025

2.13

 

P + PZQ

18.6 ± 0.5

20.2 ± 1.2

8.60

0.15 ± 0.005

0.15 ± 0.007

0.00

0.79 ± 0.015

0.77 ± 0.014

−1.50

 

PBS

18.4 ± 0.4

14.4 ± 1.1

−21.7

0.19 ± 0.027

0.24 ± 0.008

26.32

0.84 ± 0.011

0.86 ± 0.014

2.15

S. mansoni

P

18.0 ± 0.6

16.1 ± 1.1

−10.6

0.20 ± 0.010

0.24 ± 0.009

20.00

1.59 ± 0.023

1.64 ± 0.012

3.14

 

PZQ

18.0 ± 0.6

19.8 ± 0.9

10.0

0.17 ± 0.022

0.19 ± 0.011

11.76

0.83 ± 0.006

0.82 ± 0.004

−1.26

 

P + PZQ

18.6 ± 0.8

20.3 ± 0.6

9.10

0.16 ± 0.006

0.16 ± 0.005

0.00

0.83 ± 0.013

0.82 ± 0.049

−1.38

 

PBS

18.4 ± 0.9

14.5 ± 1.7

−21.2

0.20 ± 0.025

0.25 ± 0.006

25.00

1.08 ± 0.011

1.11 ± 0.009

2.77

L. major + S. mansoni

P

19.8 ± 0.2

18.2 ± 0.5

−8.08

0.22 ± 0.006

0.25 ± 0.013

13.60

1.55 ± 0.041

1.58 ± 0.032

3.20

PZQ

18.4 ± 0.3

17.0 ± 0.8

−7.60

0.22 ± 0.009

0.24 ± 0.007

9.09

1.59 ± 0.012

1.61 ± 0.011

1.95

 

P + PZQ

18.4 ± 0.6

19.8 ± 0.4

7.60

0.19 ± 0.016

0.20 ± 0.012

5.26

0.82 ± 0.012

0.83 ± 0.013

1.22

 

PBS

17.9 ± 0.9

14.4 ± 1.5

−19.6

0.21 ± 0.007

0.27 ± 0.018

28.57

1.04 ± 0.014

1.08 ± 0.017

4.24

ANOVA

Main effect

         
 

F

19.311

7.421

 

9.241

8.421

 

7.112

14.0214

 
 

p value

0.0000

0.0005

 

0.0001

0.0004

 

0.0071

0.0000

 
 

Repeated measure

         
 

F

 

9.2114

  

7.5515

  

5.5544

 
 

p value

 

0.0007

  

0.0021

  

0.0081

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