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Table 1 Macrocyclic lactones and dosages licensed in different formulations for the prevention of infestations caused by Dirofilaria immitis (Di) or Dirofilaria repens (Dr) in dogs

From: Vector-borne helminths of dogs and humans in Europe

Macrociclic lactone

Formulation

Dosage

Claim

Ivermectin

Tablets/Chewables

6 mcg/kg

Di, Dr

Ivermectin/Praziquantel

Chewables

6 mcg/kg / 5 mg/kg

Di, Dr

Milbemycin oxime*

Tablets

0.5 mg/kg

Di

Moxidectin

Tablets

3 mcg/kg

Di

 

Injectable

0.17 mcg/kg

Di, Dr

Moxidectin/Imidacloprid

Spot on

2.5 mg/Kg / 10 mg/kg

Di

Selamectin

Spot on

6 mg/kg

Di

  1. *Tablets containing either praziquantel or lufenuron are also available for chemoprevention at the same dosage (modified from [66]).