Transcriptional profiling of the murine cutaneous response during initial and subsequent infestations with Ixodes scapularis nymphs

Heinze, Dar M; Wikel, Stephen K; Thangamani, Saravanan; Alarcon-Chaidez, Francisco J

doi:10.1186/1756-3305-5-26

Table 3 Gene ontology results from genes upregulated during secondary infestation.

From: Transcriptional profiling of the murine cutaneous response during initial and subsequent infestations with Ixodes scapularis nymphs

Cluster	Terms	PValue	Cluster	Terms	PValue
Putative	Disulfide bond	0.00002	Immune cell	Positive regulation of signal transduction	0.0032
Secreted	Signal peptide	0.0038	signaling and	Positive regulation of cell communication	0.005
	Signal	0.0043	activation	Four-helical cytokine, core	0.0061
	Glycoprotein	0.013		Regulation of cell activation	0.0063
Cytokine	Immune response	0.00001		Regulation of peptidyl-tyrosine phosphorylation	0.0071
	Cytokine	0.00026		Regulation of leukocyte proliferation	0.008
	Cytokine activity	0.0013		Regulation of T cell activation	0.008
	Extracellular space	0.0019		Positive regulation of peptidyl-tyrosine phos.	0.011
	Cytokine-cytokine receptor interaction	0.0054		Regulation of lymphocyte activation	0.014
Hematopoietic	Hematopoietic cell lineage	0.0011		Regulation of leukocyte activation	0.014
lineage	T-cell	0.0032		Regulation of hematopoiesis by cytokines	0.019
	Regulation of hematopoiesis by cytokines	0.019		Regulation of mononuclear cell proliferation	0.019
Inflammation	Inflammatory response	0.027		Regulation of lymphocyte proliferation	0.019
	Defense response	0.027		Regulation of protein kinase cascade	0.02
Chemotaxis	Chemotaxis	0.0024		Positive regulation of T cell activation	0.03
	Locomotory behavior	0.0024		Regulation of cellular localization	0.033
	Taxis	0.0024		Positive regulation of protein kinase cascade	0.033
	Leukocyte adhesion	0.017		Regulation of protein modification process	0.034
	Cell chemotaxis	0.026		Regulation of cellular protein metabolic process	0.034
	Leukocyte chemotaxis	0.026		Positive regulation of immune system process	0.034
	Neutrophil chemotaxis	0.026		Regulation of chemokine production	0.039
	Leukocyte migration	0.032		Regulation of chemokine biosynthetic process	0.039
Cell surface	Monocyte and its Surface Molecules	0.0025		Positive regulation of cell activation	0.045
molecules	Cell adhesion molecules (CAMs)	0.0071		Positive regulation of protein modification process	0.047
	External side of plasma membrane	0.01		Regulation of T cell proliferation	0.047
	Cell surface	0.021	Tyrosine	Regulation of peptidyl-tyrosine phosphorylation	0.0071
T-cell regulation	Positive regulation of T cell activation	0.03	phosphorylation	Positive regulation of peptidyl-tyrosine phos.	0.011
	Regulation of cellular localization	0.033	Leukocyte	Monocyte and its Surface Molecules	0.0025
	Regulation of alpha-beta T cell differentiation	0.039	adhesion	Cell adhesion molecules (CAMs)	0.0071
	Positive regulation of alpha-beta T cell diff.	0.039		Neutrophil and Its Surface Molecules	0.0082
Sushi domain	domain:Sushi 2	0.036		Leukocyte adhesion	0.017
	domain:Sushi 1	0.036		Adhesion Molecules on Lymphocyte	0.019
	domain:EGF-like	0.036		Natural killer cell mediated cytotoxicity	0.021
Activation	Propeptide:Activation peptide	0.048
peptide

Significant gene ontology terms from genes upregulated at any time point during secondary infestation of mice with I. scapularis nymphs are shown grouped into clusters based on the functional annotation clustering tool available from DAVID.

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ISSN: 1756-3305

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