Molecular characterization of cathepsin B from Clonorchis sinensis excretory/secretory products and assessment of its potential for serodiagnosis of clonorchiasis

Table 1 Summary of difference between rCs CB ELISA and stool examinations results.

Panel A
CsCB ELISA	No. of samples from stool examination
	Negative	Positive	Total
Negative	158(81%)	17	175
Positive	38	63(79%)	101
Total	196	80	276
Panel B
Parasites	No. of serum samples		No. positive of Cs CB ELISA
Echinococcus multilocularis	22		3(14%)
Fasciola hepatica	42		15(36%)
Schistosoma japonicum	41		13(32%)
Paragonimus westermani	21		4(19%)
Taenia solium	20		2(10%)
negative	50		1(2%)
Total	196		38(19%)

Panel A: Comparison of the rCs CB ELISA with microscopic examination of stool samples as the gold standard method for diagnosis of clonorchiasis in 276 human sera. rCs CB ELISA test showed 81% specificity and 79% sensitivity with reference to stool examination. Panel B: Number of the sera from individuals infected with other helminths used for cross-reactivity tests.

ISSN: 1756-3305