Bovipain-2, the falcipain-2 ortholog, is expressed in intraerythrocytic stages of the tick-transmitted hemoparasite Babesia bovis

Table 2 Babesia bovis bovipain-2-related proteins in other apicomplexan organisms

GenBank Id	Organism	Annotation	% identity	Bovipain-2 ortholog	Ref.
ACO94081	Babesia bigemina	babesipain-1	48.5	Yes	1
BAD08222	Theileria orientalis	cysteine peptidase 2	36.6	NA	-
XP_954970	T. annulata	cysteine peptidase precursor, tacP	36.6	Yes	2
XP_763298	T. parva	cysteine proteinase	36.5	Yes	3
AAC17994	B. equi	cysteine peptidase	35.0	NA	4
XP_001615274	Plasmodium vivax	vivapain-2	29.3	Yes	-
XP_002259153	P. knowlesi	falcipain ortholog	28.8	Yes	5
XP_001347832	P. falciparum	falcipain-2B	28.5	Yes	6

Proteins with the highest scores of identity with bovipain-2 amino acid sequence (T2B strain) are shown. A Blosum 62 matrix was used to calculate identity percentages. Orthology was established by reverse BLAST against available genome sequences of corresponding organisms. NA: not applicable as the complete genome sequence was not available. References (Ref.) are as follows: (1) [35]; (2) [57]; (3) [58]; (4) [59]; (5) [26]; (6) [60].

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