Proteins in essential processes associated with apoptosis | Mitochondrial changes associated with apoptosis | Effectors of apoptosis |
---|---|---|
Proteins associated with the cell-cycle Prohibitin (T. brucei) RACK (T. brucei) QM (T. brucei) PKC (L. donovani) GSK-3 (L. donovani) CRK3 (L. donovani) | Respiration and ΔΨm Increase, Decrease | Proteases Cathepsin-like proteases (CPA, CPB, CPC) (L. major, L. mexicana) |
Proteins associated with proliferation and cell division Centrin (L. donovani) EF-1α (T. cruzi) | Mitochondrial membrane permeability ROS by lipid peroxidationb ΔΨm by mitochondrial matrix condensationa Bcl-2 functional homologuesb | Proteasomal proteases (L. amazonensis) |
Proteins involved in DNA replication Topoisomerases (Leishmania spp.) | Mitochondrial release of pro-apoptotic proteins Cytochrome c c EndoG | Metacaspases (T. cruzi, L. donovani) |
Proteins involved in nucleocytoplasmic transport Ran (T. brucei) RanBP1 (T. brucei) CAS (T. brucei) NTF-2 (T. brucei) | ΔΨm, ROS and Ca2+ interplay Trigger → Cytosolic Ca2+ elevation → Ca2+ entry into mitochondrion → Dissipation of ΔΨm → ROS | Nucleases EndoG (Leishmania spp.) |
Proteins in cytoskeletal dynamics Tubulins a (L. donovani, T. brucei) | Trigger → ROS → lipid peroxidation-→ elevation of cytosolic Ca2+ → Dissipation of ΔΨm | TatD-like endonuclease (L. donovani) |
Proteins in other processes SIR2 deacetylase (L. infantum) | Trigger → ROS → ΔΨm → intracellular Ca2+ elevation | Flap-endonuclease-1 (L. donovani) |