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Table 1 Comparative pharmacokinetics of moxidectin (MOX) and ivermectin (IVM) after oral administration in horses expressed as mean (± SD)

From: Moxidectin: a review of chemistry, pharmacokinetics and use in horses

 

IVM

MOX

Dose (mg/kg)

0.2

0.4

Cmax (μg/mL)

44.0 (± 23.1)

70.4 (± 10.7)

Tmax (day)

0.38 (± 0.24)

0.37 (± 0.19)

T1/2 elim (day)

4.25 (± 0.29)

23.11 (± 11.0)

AUC 0-t (μg/day/mL)

132.7 (± 47.3)

363.6 (± 66.0)

  1. Cmax = Maximum concentration
  2. Tmax = Time for maximum concentration
  3. T1/2 = Terminal half-life
  4. AUC = Area Under the concentration vs. time Curve